‘Tree Man’ Has Surgery: What Causes This Rare Condition?

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‘Tree Man’ Has Surgery: What Causes This Rare Condition?



Surgeons shocked to find fully formed teeth in a baby’s brain tumor

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Surgeons shocked to find fully formed teeth in a baby’s brain tumor

2/27/14 2:20pm

Sometimes, when biology goes squirrely, it really goes squirrely. Case in point, a bizarre medical case in which a 4-month-old infant in Maryland was found to have several fully formed teeth embedded within a brain tumor. Warning: Graphic image to follow.

The boy was admitted to hospital because his head was growing faster than normal. Subsequent MRI scans showed a “heterogeneous, enhancing suprasellar mass” — but it contained multiple structures along the right side that looked startlingly like teeth that form in the lower jaw.

During the procedure to remove the tumor, the surgeons encountered multiple fully formed teeth. Fully formed! And not just bits of enamel or calcium deposits.

Subsequent analysis of the tumor revealed a craniopharyngioma, a rare brain tumor that can grow to be larger than a golf ball, but does not spread.LiveScience‘s Rachael Rettner explains more:

Researchers had always suspected that these tumors form from the same cells involved in making teeth, but until now, doctors had never seen actual teeth in these tumors, said Dr. Narlin Beaty, a neurosurgeon at the University of Maryland Medical Center, who performed the boy’s surgery along with his colleague, Dr. Edward Ahn, of Johns Hopkins Children’s Center.

“It’s not every day you see teeth in any type of tumor in the brain. In a craniopharyngioma, it’s unheard of,” Beaty said.

Craniopharyngiomas commonly contain calcium deposits, “but when we pulled out a full tooth…I think that’s something slightly different,” Beaty told Live Science.

Teeth have been found in people’s brains before, but only in tumors known as teratomas, which are unique among tumors because they contain all three of the tissue types found in an early-stage human embryo, Beaty said. In contrast, craniopharyngiomas have only one layer of tissue.

The boy’s case provides more evidence that craniopharyngiomas do indeed develop from the cells that make teeth, Beaty said.

Incredibly, the boy is doing well, but the tumor destroyed his capacity to release certain hormones, so he’ll have to undergo hormone treatments for the rest of his life.

Read more at LiveScience. The entire report can be found at the New England Journal of Medicine: “Adamantinomatous Craniopharyngioma Containing Teeth.”


Miniature Brain and Skull Found Growing Inside Teen’s Ovary

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Miniature Brain and Skull Found Growing Inside Teen’s Ovary

Yesterday 11:17am

The teratoma contained bits of hair, skull, and surprisingly well-formed brain matter. (Image: Masayuki Shintaku et. al., 2017)

While performing a routine appendectomy on a 16-year-old girl, Japanese surgeons uncovered an ovarian tumor containing bits of hair, a thin plate of bone—and a miniature brain.

The unusual teratoma—a tumor containing tissue or organ components—measured four-inches (10 cm) across, so it was hard to miss. Analysis revealed clumps of greasy, matted hair, and a one-inch-wide (3 cm) brain-like structure covered by a thin, rudimentary skull.

Disturbingly, the miniature brain contained a brainstem-like structure, and a large amount of highly organized and differentiated cerebellum tissue. The cerebellum is a brain-part that sits below the two hemispheres, and is responsible for motor control, and some cognitive functions such as attention and language. But don’t worry—there’s no way this chunk of brain matter could feel or think.

Analysis of the mini-brain revealed highly differentiated and well-organized structures reminiscent of what’s found in the cerebellum. (Image: Masayuki Shintaku et. al., 2017)

Not to be confused with parasitic twins, teratomas happen when the cells inside organs go a bit squirrely, expressing parts of other organs and tissues that belong elsewhere in the body. These congenital tumors have been found to contain bits of hair, teeth, bone, and in some rare cases, eyes, torsos, hands, and feet. The exact cause is not known, but in the case of ovarian teratomas, it may be caused by glitching immature egg cells. Teratomas are known to happen in organs such as the brain, thyroid, liver, lung, and ovaries.

Brain cells have been observed in ovarian teratomas before, but as Japanese researcher Masayuki Shintaku told New Scientist, it’s extremely unusual for them to organize themselves into proper brain-like structures. Incredibly, the mini-brain was capable of transmitting electric impulses between neurons, just like a normal brain.

The girl didn’t express any symptoms, but teratomas are known to trigger psychological problems, such as personality changes, paranoia, confusion, agitation, seizures, and memory loss. This likely happens as a result of the body trying to get rid of the alien brain matter—but in so doing, mounts a double-attack that also affects the brain.

Thankfully, teratomas are relatively benign, and relatively easy to remove with surgery. The 16-year-old girl had her teratoma removed, and she’s made a full recovery.

[Neuropathology via New Scientist]

George is a contributing editor at Gizmodo and io9.

Your Crappy American Diet Might Leave Your Gut Bacteria Stunted

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Your Crappy American Diet Might Leave Your Gut Bacteria Stunted

Thursday 2:08pm

Image: Rocky Mountain Laboratories/Wikimedia Commons

Adopting a healthy lifestyle might not seem that hard on the outset. You ate a lot of cheeseburgers and drank a lot of soda, and now you’re going to stop doing that. But a new study in mice suggests that it takes a while for the gut’s bacterial zoo, or microbiome, to adapt to dietary changes. If the results hold in humans, it could mean developing a healthy gut is more than a quick diet fix.

The study, which is published today in the journal Cell Host and Microbe, involved plenty of poop. The researchers first analyzed feces from a group of people who stuck to a calorie-restricted diet that optimized their nutrient intake, and another group of people who ate a so-called American diet without dietary restrictions. Then, the team raised an array of mice whose gut microbiomes included the human fecal bacteria associated with the two diets, fed these mouse models the two different diets, and measured their weight and gut bacterial makeup periodically. In another experiment, the researchers housed calorie-restricted mice and American diet mice together, and again observed how each group’s microbiome responded to either diet.

The scientists found that poop from the American diet eaters had fewer species of bacteria than poop from calorie-restricted dieters. And even after being moved to a better diet, the mice raised with an American diet-microbiome exhibited lower bacterial diversity. However, the American diet-raised mouse microbiomes responded more strongly to their new healthy diets once they moved into communities with the calorie-restricted mice.

According to Andy Benson, a professor of biotechnology at the University of Nebraska, Lincoln who was not involved with the study, the research is important for showing that different diets have an impact on the configuration of the microbiome. However, he noted a few caveats, like the fact that mice aren’t people. “The more difficult part is how we extrapolate these results to human populations,” he said. He also noted that plenty of other factors determine the microbiome other than just diet.

Benson worried that folks would get too excited about the fact that housing mice together helped American diet eaters with stunted gut microbiome diversity become more diverse. (In general, more diversity is a good thing for any ecosystem, including the gut, and we probably evolved eating a diet closer to the diversity-promoting calorie-restricted one.)

The study “definitely generates some thought, and it’s an interesting discussion among scientists. It mortifies me to think of politicians thinking about this,” he said. Plus, he wasn’t sure how this effect would manifest itself in human populations. The paper’s authors use the word “coprophagic,” meaning shit-eating, while discussing how gut bacteria might be passed between mice raised on different diets, and while they did not respond to a request for comment, I doubt people looking to live more healthy will eat the poop of dieting people.

Alessio Fasano, a pediatric gastroenterologist from Massachusetts General Hospital, speculated about what the results might mean for humans. “There’s a well-established [microbial] community dictated by prior dietary practice,” he said. “Even if you make changes in the diet, the microbiome will be hard to modify.”

Fasano emphasized that scientists aren’t so sure if a microbiome lacking diversity is the cause or consequence of gastrointestinal problems. “But when you take a cross section of people who are sick, say with Crohn’s disease, we know the differences in their microbiome are an integral part.”

[Cell Host and Microbe]

Science writer at Gizmodo | I like physics and eating

Scary Imaging Shows Baby’s Legs Ripping Through the Mother’s Uterus

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Scary Imaging Shows Baby’s Legs Ripping Through the Mother’s Uterus

Thursday 11:30am

Scans revealed a tear in the uterus, with the baby’s feet sticking right into the amniotic sac. (Image: NEJM, Pierre-Emmanuel Bouet, Centre Hospitalier Universitaire d’Angers, Angers, France)

A scary scan taken at the 22 week mark of a 33-year-old woman’s pregnancy revealed a baby with its feet extending right through the mother’s uterus, and its protective amniotic sac right along with it.

As reported in the New England Journal of Medicine, the 33-year-old mother, who had no idea anything was wrong, was in for a regular checkup when the rupture was detected. Ultrasounds and a subsequent MRI revealed a 1-inch (2.5 cm) rupture of the left uterine wall, and an unusually large herniated amniotic sac containing the baby’s very discernible legs (normally, the baby is fully inside this fluid-filled sac, which contains and protects the fetus in the womb).

Doctors informed the parents of the potential risks. With part of the uterine wall breached, the mother was a risk of having her entire uterus ruptured. A life-threatening condition known as “placenta accreta” was also possible, where blood vessels and other parts of the placenta grow too deeply into the uterine wall, potentially leading to heavy bleeding after birth. The mom was also at risky of having to have a hysterectomy and giving birth to a premature baby (normal pregnancies are around 39-40 weeks).

Undaunted, the parents decided to go through with the pregnancy, but with close monitoring. The mother was told that bedrest was not required, and that she could go about her pregnancy as per normal.

Image: NEJM, Pierre-Emmanuel Bouet, Centre Hospitalier Universitaire d’Angers, Angers, France

The OB/GYN who attended to the case, Dr. Pierre-Emmanuel Bouet from Angers University Hospital in France, said he had never seen a case like this before, telling Live Science the condition is “very rare” and that only 26 similar cases exist in the literature.

This was the mother’s sixth pregnancy, the previous five ending with cesarean sections. Bouet said the areas in which the uterus had scarred after the mother’s previous C-sections were strong, but the regions around it had weakened. The weight of the baby, plus the pressure on the uterus, ultimately led to the rupture.

By week 30 of the pregnancy, the uterine tear had grown to an alarming two inches (5 cm), and the herniated sac had grown so much it enveloped the baby right up to its abdomen. At this point, the doctors decided to schedule a cesarean section, yielding a 3-pound baby boy.

After the delivery, the doctors patched up the rupture, and the sac was repaired. The mother recovered quickly and was discharged from the hospital after just five days. Six months after the birth, the baby is reported as doing fine and well.

[NEJM, Live Science]

George is a contributing editor at Gizmodo and io9.

New Test Could Improve Diagnosis of Rare, Fatal Brain Disorder

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10 Weird Ways Disease Altered The World

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10 Weird Ways Disease Altered The World


Diseases leave obvious imprints on history. A decrease in population size and less genetic diversity are some examples of the impact you’d expect every epidemic to have. However, every once in a while, a disease has a truly remarkable and unusual effect on the world.

10Flu Of 1918 And The Treaty Of Versailles


Photo credit: Edward N. Jackson

The Flu of 1918 devastated the world and infected one-third of the population. Additionally, it damaged brain cells, affecting the brain’s ability to function and even resulting in psychosis. In April 1919, Woodrow Wilson became infected with the flu. Wilson was president at the time and played an instrumental role in the negotiations of the Treaty of Versailles, particularly standing up the France’s prime minister, Georges Clemenceau, who wanted to dismantle Germany.

As Wilson was recovering from the flu, many White House officials noted a change in his demeanor. Wilson was described as slow, tired, and focused on strange notions. After these odd reports, Wilson abandoned many of his ideas about the Treaty, which gave power to Clemenceau. Many argue that the harshness of the Treaty of Versailles resulted in disaster for Germany, the crippling of the German economy, and played a role in Hitler’s ability to gain power. All of this could be the result of Woodrow Wilson’s bout of the flu.


9Tuberculosis And Expansion Of Western Frontier


Photo credit: George Caleb Bingham

During the tuberculosis outbreak of the 1900s, many believed in miasma theory, the belief that sickness is caused by bad air and pollution. The idea was promoted by Edward Trudeau, a doctor from New York who was infected with tuberculosis and, after moving to the Adirondacks, noticed an improvement in his condition. He began spreading the news that fresh air and nature were a cure.

Upon hearing this, thousands of Americans moved west in search of better health, and many campaigns for western expansion were targeted toward “health seekers.” People infected with tuberculosis migrated in large numbers with pioneers and explorers.

8Cholera And The Rise Of Epidemiology


Photo credit: Wikimedia

In 1854, John Snow removed the handle of a water pump and created an entire branch of medicine.

Snow, a physician during the cholera epidemic in London, was suspicious of the way the disease was spreading. He rejected the miasma theory and observed how clusters of disease were popping up among people who used certain water pumps.

His intervention of removing the infected pump handle helped decrease the rates of infection during the epidemic. Additionally, he was the first to use epidemiological methods to control the spread of disease.


7Hookworm And Economic Development In The South


Photo credit: CDC

Hookworm is a parasite that lives in the human intestine, feeds on human nutrients, and can be transmitted through fecal matter. Hookworm can cause a rash and diarrhea, but hookworm disease can lead to more chronic symptoms. In the South during the early 1900s, hookworm disease slowly rose to epidemic proportions and resulted in lethargy, iron deficiency, and stunted growth.

Over time, symptoms of hookworm helped create stereotypes about Southerners being drawling, unindustrious, or lazy. After the epidemic was identified and efforts were made to prevent infection, the South saw more children enrolling in school, better crop prices, and a rise in income.

6Tuberculosis’s Effect On Fashion


Photo credit: Wikimedia

In the late 1800s, tuberculosis, an infectious disease of the lungs, had become an epidemic in the US and Europe. Since the disease was around for so long and killed very slowly, its qualities started to be romanticized in the Victorian era. Fashions characterized by being pale and slim became popular, and the disease itself became trendy.

When scientists learned more about the illness in the 1900s, they sparked some of the first major public health campaigns in the US. Hemlines for women’s dresses and skirts became shorter to prevent them from picking up tuberculosis on the street. Beards and mustaches were exchanged for a clean shave because of the possibility that bacteria could be living in facial hair.

5Bubonic Plague And The Catholic Church


Photo credit: Henri Segur

The bubonic plague devastated Europe in the 14th century. One of the most lasting effects, however, was the plague’s impact on the Catholic Church, which lost significant support as massive numbers of people were dying.

Many citizens looked to the Church for answers about why the plague was killing so vigorously and what could be done to stop it. When the Church was unable to give an explanation or help, many people questioned their faith and lost confidence in God. This resulted in an era where religion became less attached to people’s lives. This also allowed for pioneering work to be done in modern medicine and progress that may not have been possible if people’s faith had been maintained or even strengthened by the plague.


4Tuberculosis And Sanatoriums


Photo credit: Wikimedia

As the tuberculosis epidemic continued in the late 1800s, the theory of fresh air and nature as a cure for spread far and wide. This resulted in the construction of sanatoriums, facilities to give supportive care to TB patients—specifically, rest and fresh air because no other treatment was known. Patients would be sent to live in sanatoriums for years at a time, which created an entire subculture surrounding these facilities. There were many children who spent much of their childhoods there.

Patients would have to surrender their rights to undergo treatment and were forced to lay in reclining chairs, outside, with blankets piled on top of them so they could breathe the fresh air and stay warm. The resort-like characteristics promoted relaxation but was always in the shadow of death and disease.

Once antibiotics were discovered, tuberculosis could be cured almost instantly, and the need for sanatoriums disappeared.

3Smallpox And Columbian Exchange


Smallpox can be spread by bodily fluids or objects that have been contaminated. To date, it is the only disease that has been eradicated.

In the 1500s, during the Columbian Exchange between Europe and the New World, smallpox devastated Native inhabitants, killing up to 90 percent of the population. This disease was also used as a method for biological warfare by European explorers who were colonizing the Americas. Native populations had no built up immunity to the diseases that Europeans brought over and were torn apart by the virus. Entire civilizations were wiped out, taking with them cultures, forms of art, and languages that are now lost forever.

2Yellow Fever And The Louisiana Purchase


Photo credit: William Morris

Yellow fever is transmitted by mosquitoes that live in tropical climates. In the early 1800s, it played a role in the Louisiana Purchase by weakening the French army.

Napoleon, leader at the time, planned to occupy the West and expand France’s influence around the world. French troops were stationed in Haiti when Haitian slaves rebelled successfully, defeating the French military. This was due to high rates of yellow fever among French troops, which weakened them and rendered them unable to fight back. In response to this, Napoleon offered up the whole Louisiana territory.

In the end, the purchase was settled as a treaty, allowing the land to beextremely inexpensive. Without yellow fever and the Haitian Slave Rebellion, The United States may have looked very different.

1Plague Of Athens


The Plague of Athens is an unidentified disease that struck in 400 BC, killing 25 percent of Athens’s population. While no one has confirmed what the disease was, likely candidates are smallpox and typhoid fever.

The plague took the life of Pericles, a major leader to Athenians, which damaged their ability to fight in the Peloponnesian War. Another damaging factor was the significant decrease in the population, which affected their ability to mobilize militarily. This contributed further to the loss of the Peloponnesian War, which affected the course of history by defining which groups were in power in Ancient Greece.

Sofia is a student on the east coast who is interested in diseases and history. She enjoys reading Listverse and learning new things about history, politics, but mostly just unusual facts.